Leveraging Breath Analysis for Clinic Growth in IV Therapies and GLP1s

Welcome to this edition of the PNOĒ Webinar Series, where healthcare professionals, clinic owners, and wellness entrepreneurs explore how breath analysis and metabolic testing can be leveraged to improve clinical outcomes while driving sustainable business growth.

In this session, we focus on how PNOĒ metabolic breath analysis is being used in real-world clinical settings particularly in IV therapy clinics, weight management programs, and GLP1–based treatments to enhance patient engagement, personalize care, and differentiate services in a competitive healthcare landscape.

Together with Dr. Catie Harris, Nurse Practitioner and founder of multiple healthcare businesses, we examine how objective metabolic data such as resting metabolic rate (RMR),  VO2 Max, fat oxidation, and respiratory exchange ratio (RER) can transform both patient education and clinic workflows.

This webinar is designed for providers looking to integrate evidence-based metabolic insights into their practice without adding operational complexity while improving retention, outcomes, and revenue.

Discover how PNOĒ bridges clinical precision with scalable business models in modern healthcare.

Follow PNOĒ on Instagram: @pnoe_analytics

Panos Papadiamantis:
Hello everyone, and welcome. I’m Panos Papadiamantis from PNOĒ, and I’m excited to have you joining us for today’s webinar.

In this session, we’ll be discussing how PNOĒ breath analysis is being used by nurse practitioners and other healthcare professionals, with a particular focus on IV therapy clinics and GLP1–based weight management programs. I’m joined today by Dr. Catie Harris, and I’m very grateful for her time and insights.

Dr. Catie Harris:
Thank you so much, Panos. I’m really excited to be here and to share how this technology has impacted both my clinical practice and my businesses.

Panos Papadiamantis:
Today’s structure is straightforward. Dr. Harris will start by sharing her background and the businesses she operates. I’ll then provide a brief overview of PNOĒ and breath analysis, and finally we’ll dive into real-world use cases, success stories, and operational efficiencies from her clinic.

Dr. Catie Harris:
I run a business called NursePreneurs, which helps nurses start and scale healthcare businesses. I also operate the Philly Wellness Center, where I maintain my clinical practice.

After working with PNOĒ for the past year, I felt it was essential to share this with other providers. It has been a true game changer for our clients especially those receiving IV hydration therapy or GLP1 medications such as semaglutide.

Dr. Catie Harris:
NursePreneurs was founded about eight years ago with the goal of helping nurses identify viable business niches and build sustainable service lines. We support them with business setup, marketing, and operational strategy whether they’re launching IV clinics, wellness centers, or other healthcare services.

Panos Papadiamantis:
That support is critical. Many clinicians are highly skilled medically but need guidance when it comes to integrating clinical care with business strategy especially in competitive markets.

I’ll now provide a brief overview of PNOĒ and the fundamentals of breath analysis to ensure everyone is aligned.

Panos Papadiamantis:
Breath analysis has been used for nearly a century as a gold-standard method for understanding energy expenditure and human metabolism. Over time, it has been applied in cardiology, pulmonology, nutrition science, and exercise physiology.

Many people know it as  VO2 Max testing or metabolic testing, but these are only two of the 23 biomarkers generated through comprehensive breath analysis.

Panos Papadiamantis:
Breath analysis allows us to assess the oxygen chain how oxygen moves from the lungs, through the heart, and into the cells. It also provides insight into nervous system function, posture, and overall metabolic health.

This methodology has been endorsed by organizations such as the American Heart Association and the American Thoracic Society.

Panos Papadiamantis:
Historically, metabolic testing was expensive, complex, and limited to specialized facilities. PNOĒ was built to remove those barriers by offering a portable, clinically accurate system that integrates testing, analysis, and personalized recommendations into a single platform.

The system delivers clinical-grade accuracy, automated interpretation, and personalized nutrition and training plans making breath analysis accessible across a wide range of clinical and wellness settings.

Panos Papadiamantis:
From a technical standpoint, breath analysis is based on three primary signals: oxygen concentration, carbon dioxide concentration, and airflow volume. These are measured on a breath-by-breath basis and translated into actionable biomarkers such as RMR,  VO2 Max, O2 pulse, and fat oxidation rates.

Panos Papadiamantis:
One particularly important metric especially for GLP1 patients is the respiratory exchange ratio (RER). RER reflects whether the body is primarily burning fat or carbohydrates and is increasingly being used in pharmaceutical research to evaluate metabolic effectiveness.

Panos Papadiamantis:
Another key concept is the crossover point, which represents the exercise intensity at which carbohydrate oxidation surpasses fat oxidation. A later crossover point is associated with better metabolic health and greater mitochondrial efficiency.

This metric is highly valuable for assessing metabolic dysfunction and tracking improvement over time.

Panos Papadiamantis:
We also use breath analysis to assess biological age, calculated primarily from  VO2 Max, one of the strongest predictors of mortality and morbidity risk.

Additional insights include metabolic rate, optimal caloric intake, macronutrient distribution, and individualized exercise zones.

Panos Papadiamantis:
With that foundation, I’d like to turn it over to Dr. Harris to discuss how these insights translate into real-world clinical and business outcomes.

Dr. Catie Harris:
In my clinic, we focus on hormone therapy and weight management. Before PNOĒ, many patients struggled with weight loss and didn’t understand why progress was stalled.

One of the most impactful metrics for our patients has been resting metabolic rate. Many GLP1 patients drastically under-eat, sometimes consuming fewer than 1,000 calories per day, which negatively impacts overall physiology.

Dr. Catie Harris:
PNOĒ allows us to objectively guide patients toward adequate caloric intake, appropriate macronutrient balance, and realistic expectations without requiring me to become a full-time nutritionist or exercise physiologist.

The platform effectively acts as an extension of my clinical team.

Dr. Catie Harris:
This is especially important for small practices. PNOĒ enables comprehensive metabolic coaching without hiring additional staff, while clearly differentiating our clinic from mail-order GLP1 providers.

Panos Papadiamantis:
We see this consistently across practices of all sizes. Whether it’s a solo clinic or a multi-location organization, automation and personalization are essential for scalability and retention.

Panos Papadiamantis:
From your experience, which insights resonate most strongly with patients?

Dr. Catie Harris:
Without question, metabolic age. When a patient sees that their metabolic age is significantly higher than their chronological age, it creates immediate motivation.

When combined with body composition and fat oxidation data, the message becomes undeniable and drives engagement with treatment plans.

Dr. Catie Harris:
RER is another powerful metric. When patients arrive fasted but are still primarily burning carbohydrates, it’s a clear indicator of metabolic dysfunction no lab work required.

Panos Papadiamantis:
That third-party objectivity is key. Breath analysis provides immediate, non-invasive validation and makes retesting easy, which reinforces adherence over time.

Dr. Catie Harris:
Exactly. Retesting allows patients to visually see improvement, which builds trust and long-term commitment.

Panos Papadiamantis:
From a business standpoint, how do you integrate PNOĒ into your model?

Dr. Catie Harris:
We test nearly everyone who walks through the door. In many cases, we offer testing as part of the initial experience because the downstream value is significant.

We also use PNOĒ as a lead-generation tool at events and conferences. People are highly motivated to learn their  VO2 Max and metabolic profile.

Dr. Catie Harris:
For weight-loss–resistant patients, we typically retest quarterly. We’re also increasingly collaborating with personal trainers to integrate active metabolic testing into performance programs.

Panos Papadiamantis:
We’ve seen similar success in corporate wellness, where free RMR testing serves as an entry point for broader service adoption.

Dr. Catie Harris:
Another advantage is how the PNOĒ report recommends services such as IV therapy, red light therapy, or nutrition support based on objective data. This removes the perception of upselling and positions care as data-driven.

Panos Papadiamantis:
That ability to validate interventions with retesting is crucial for retention and perceived value.

Dr. Catie Harris:
Absolutely. Patients want proof that what they’re investing in is working and breath analysis provides that proof.

Panos Papadiamantis:
Thank you, Dr. Harris, for sharing these insights. This has been an excellent discussion on how PNOĒ breath analysis supports both clinical outcomes and business growth.

This session has been recorded and will be available on our YouTube channel. For those interested in integrating PNOĒ into their practice, our team has shared a link to schedule a conversation.

Watch the full episode HERE.