Mastering the PNOĒ Journey: Dr. G’s Formula for Credibility & Growth

Welcome to this edition of the PNOĒ Webinar Series, where experienced clinicians and practice owners share real-world strategies for improving patient outcomes while building credible, scalable healthcare businesses.

In this session, we focus on how breath analysis and cardio-metabolic testing can be systematically integrated into clinical practice to enhance longevity outcomes, increase patient retention, and establish long-term professional credibility.

Joined by Dr. Steven Geanopulos, we explore a practical, evidence-based framework for delivering a complete PNOĒ journey from assessment to education to long-term behavior change. This discussion bridges metabolic testing,  VO2 Max, fat oxidation, and mitochondrial health with real clinical workflows that support both health span and business growth.

This webinar is designed for healthcare professionals who want to move beyond symptom management and toward measurable metabolic optimization, while creating a clear, trustworthy value proposition for patients seeking performance, resilience, and longevity.

Discover how PNOĒ breath analysis becomes a cornerstone for sustainable clinical impact and practice growth.

Follow PNOĒ on Instagram: @pnoe_analytics

Panos Papadiamantis:
Hello everyone, and welcome. I’m Panos Papadiamantis, Co-Founder of PNOĒ. I’m very excited to be joined today by Dr. Steven Geanopulos, joining us from the United States.

Dr. Geanopulos is a highly experienced healthcare professional and a long-time PNOĒ user. He has worked with a wide range of clients and has seen firsthand how metabolic testing improves retention, health outcomes, and overall practice performance.

I’ll first ask Dr. Geanopulos to share his background. After that, I’ll provide a brief overview of PNOĒ and breath analysis so we’re all aligned, and then we’ll move into the core discussion how he structures the complete PNOĒ experience in his practice.

Dr. Steven Geanopulos:
Thank you, Panos. It’s great to be here. PNOĒ has become a significant part of both my clinical practice and my personal health journey.

I’ve been practicing for over 23 years, primarily in Manhattan. Following the pandemic, I transitioned part of my work toward supporting other doctors across the country, while remaining actively involved in patient care. Staying in practice is extremely important to me because healthcare evolves constantly, and credibility comes from real-world application.

Dr. Steven Geanopulos:
I’m a chiropractor with postgraduate training in neurology. Much of my career has focused on brain-based disorders, including sports concussion. When you work extensively with the brain and nervous system, you quickly realize that metabolic health is always involved.

Over time, my practice evolved into what I consider a three-pillar model: structural health, neurological health, and metabolic health. Initially, that metabolic focus came through blood chemistry, and now it’s supported by cardio-metabolic testing using PNOĒ.

Dr. Steven Geanopulos:
The pandemic highlighted something critical: the metabolic health of our population is deeply compromised. Traditional healthcare often focuses on crisis management rather than improving metabolic resilience, reversing dysfunction, or supporting longevity.

Chiropractic and integrative practitioners are uniquely positioned here. We are trained in diagnostics, assessments, and functional care. Weight loss is often discussed, but weight loss is really a downstream effect. What we’re actually addressing is metabolic health, with body composition changes being a secondary outcome.

Panos Papadiamantis:
Thank you for that context. I’ll now provide a brief overview of breath analysis and the PNOĒ system so we can move into how this is applied in practice.

Panos Papadiamantis:
Breath analysis has been used for nearly a century and is often referred to as  VO2 Max testing or metabolic testing. We use the term breath analysis because it captures far more than just  VO2 Max or metabolic rate.

It was the first scientific method used to quantify energy expenditure, and over decades it became foundational in cardiology, pulmonology, nutrition science, and exercise physiology. Today, it is widely recognized as a gold-standard assessment for understanding human metabolism.

Panos Papadiamantis:
Breath analysis allows us to evaluate the oxygen chain of the heart, lungs, and cells as well as nervous system function, breathing mechanics, posture, and cognition. Together, these systems define metabolic efficiency.

Despite its value, breath analysis was historically underutilized because systems were expensive, complex, and required extensive expertise to interpret and act upon.

Panos Papadiamantis:
At PNOĒ, we addressed these barriers by creating a portable, easy-to-use device; automating the analysis of all 23 metabolic biomarkers; and coupling the test with personalized nutrition and training programming supported by experts.

Patients don’t just want data they want to know how to improve it. PNOĒ bridges that gap.

Panos Papadiamantis:
Technically, breath analysis measures three primary signals: airflow, oxygen concentration, and carbon dioxide concentration, captured breath-by-breath. From these, we derive biomarkers such as  VO2 Max, resting metabolic rate, fat oxidation, O2 pulse, and ventilatory efficiency.

These biomarkers offer a broad yet precise view of metabolic and cardio-respiratory health.

Panos Papadiamantis:
Testing includes a resting metabolic rate assessment and an active metabolic test. From these, we calculate biological age, caloric needs, macronutrient requirements, fat and carbohydrate utilization, and individualized training zones.

Zone 2 training, in particular, is critical for mitochondrial biogenesis and metabolic flexibility and must be personalized rather than estimated.

Panos Papadiamantis:
Another key aspect is integration. PNOĒ aligns test results with the services offered in a practice such as IV therapy, red light therapy, or recovery modalities providing objective justification for personalized recommendations. This personalization significantly improves adoption and retention.

With that overview, I’d like to turn it back to Dr. Geanopulos to explain how he translates this into a seamless patient experience.

Dr. Steven Geanopulos:
Thank you, Panos. For me, the value of PNOĒ lies in simplifying complexity for both clinicians and patients.

Metabolism is how we convert food and stored body tissue into energy. How efficiently someone does this determines not only weight, but body composition, performance, resilience, and aging.

I often explain it using an engine analogy. If energy intake exceeds energy use, the system overflows. You can reduce intake, but you can also increase the size of the engine and the storage capacity. Muscle mass is the storage tank. Mitochondria are the engines.

Dr. Steven Geanopulos:
As we age, we lose muscle and mitochondrial density unless we intervene. This is why zone 2 training, fat oxidation, and mitochondrial health are foundational not optional for longevity.

What we see with many weight-loss approaches, including GLP-1 medications, is initial success followed by metabolic decline. Resting metabolic rate drops, muscle is lost, mitochondria are lost, and weight regain becomes almost inevitable.

Dr. Steven Geanopulos:
This is where PNOĒ becomes invaluable. A simple 10-minute resting test reveals far more than calorie needs. We can identify thyroid dysfunction, breathing inefficiencies, nervous system stress, and even postural contributors to injury risk.

I’ve had cases where hypothyroidism was missed by standard labs but clearly reflected in a suppressed metabolic rate on PNOĒ testing.

Dr. Steven Geanopulos:
  VO2 Max and training zones are equally powerful. Generic formulas often overestimate zone 2, pushing patients into excessive carbohydrate reliance, inflammation, and fatigue. Personalized zones correct this and immediately improve outcomes.

Panos Papadiamantis:
One of the most telling visuals from active testing is the fat-to-carbohydrate crossover point. As metabolic health improves, this crossover shifts to higher intensities reflecting greater mitochondrial density and oxygen utilization.

Dr. Steven Geanopulos:
Exactly. This isn’t just about fat loss. The brain and postural muscles are highly mitochondrial tissues. Preserving mitochondrial function supports cognition, balance, movement quality, and independence as we age.

 VO2 Max trajectories also allow us to project future functional decline. With this data, we can intervene early improving health span, not just lifespan.

Dr. Steven Geanopulos:
In my practice, we use five core assessments:  VO2 Max and RMR, comprehensive blood work, body composition, strength, and movement quality. These are objective, trackable, and strongly supported by decades of research.

We reassess periodically and apply simple, sustainable interventions zone 2 training, resistance work, breathing strategies, and targeted recovery tools.

Dr. Steven Geanopulos:
This model works especially well for individuals between 40 and 80 who want longevity, vitality, and independence. These patients value data, education, and long-term planning and they are willing to invest in it.

Panos Papadiamantis:
Thank you, Dr. Geanopulos. This discussion clearly illustrates how PNOĒ breath analysis supports better outcomes, stronger retention, and scalable practice growth without adding unnecessary complexity.

For those interested in integrating PNOĒ into their practice, our team will share a link to schedule a conversation and explore implementation options.

Watch the full episode HERE.